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Richard L Piekarz Selected Research

romidepsin (FK228)

7/2015Romidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative data.
5/2015CCR 20th Anniversary Commentary: Expanding the Epigenetic Therapeutic Portfolio.
8/2013Phase I trial of a new schedule of romidepsin in patients with advanced cancers.
6/2013Electrocardiographic studies of romidepsin demonstrate its safety and identify a potential role for K(ATP) channel.
5/2013MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor.
10/2012A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®)).
4/2012Romidepsin: a new drug for the treatment of cutaneous T-cell lymphoma.
6/2011Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma.
1/2010Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma.
11/2009Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma.
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Richard L Piekarz Research Topics

Disease

14Neoplasms (Cancer)
01/2020 - 03/2002
11T-Cell Lymphoma (Lymphoma, T Cell)
07/2015 - 06/2004
9Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
07/2015 - 06/2006
6Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
07/2015 - 02/2009
2Breast Neoplasms (Breast Cancer)
10/2021 - 12/2019
2Circulating Neoplastic Cells
01/2020 - 03/2006
2Lung Neoplasms (Lung Cancer)
12/2019 - 02/2011
2Cardiotoxicity
06/2013 - 03/2002
1Hypersensitivity (Allergy)
12/2019
1Dizziness (Lightheadedness)
12/2019
1Hypoxia (Hypoxemia)
12/2019
1Nausea
12/2019
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2019
1Vomiting
12/2019
1Genetic Translocation (Chromosomal Translocation)
10/2018
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2018
1Adenoid Cystic Carcinoma (Cylindroma)
05/2017
1Thyroid Neoplasms (Thyroid Cancer)
08/2013
1Cardiac Arrhythmias (Arrythmia)
06/2013
1Hypoalbuminemia
06/2013
1Hematologic Neoplasms (Hematological Malignancy)
10/2012
1Uterine Cervical Neoplasms (Cancer of the Cervix)
02/2011
1Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
12/2010
1B-Cell Lymphoma (Lymphoma, B Cell)
12/2010
1Chromosome Aberrations (Chromosome Abnormalities)
12/2010
1Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
06/2009
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
06/2009
1Kidney Neoplasms (Kidney Cancer)
03/2006

Drug/Important Bio-Agent (IBA)

16romidepsin (FK228)FDA Link
07/2015 - 03/2002
15Histone Deacetylase InhibitorsIBA
10/2021 - 03/2002
7DepsipeptidesIBA
05/2015 - 03/2002
3belinostatIBA
12/2019 - 06/2009
2entinostat (MS 275)IBA
10/2021 - 06/2009
2MethyltransferasesIBA
01/2020 - 06/2009
2DNA (Deoxyribonucleic Acid)IBA
01/2020 - 06/2009
2VorinostatFDA Link
05/2017 - 06/2009
2Histones (Histone)IBA
08/2013 - 03/2006
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
05/2013 - 02/2011
2Pharmaceutical PreparationsIBA
04/2012 - 02/2011
2Antineoplastic Agents (Antineoplastics)IBA
11/2009 - 06/2004
1exemestane (Aromasin)FDA Link
10/2021
1Hormones (Hormone)IBA
10/2021
1Aromatase InhibitorsIBA
10/2021
1human ERBB2 proteinIBA
10/2021
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
01/2020
1Cyclin-Dependent Kinase Inhibitor p16IBA
01/2020
1TetrahydrouridineIBA
01/2020
15-fluoro-2'-deoxycytidineIBA
01/2020
1Isotretinoin (Accutane)FDA LinkGeneric
12/2019
1Tretinoin (Retinoic Acid)FDA LinkGeneric
12/2019
1Poly(ADP-ribose) Polymerase InhibitorsIBA
10/2018
11,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA
10/2018
1talazoparibIBA
10/2018
1Etoposide (VP 16)FDA LinkGeneric
01/2018
1Cisplatin (Platino)FDA LinkGeneric
01/2018
1Histone Deacetylases (Histone Deacetylase)IBA
05/2015
1IodineIBA
08/2013
1PotassiumIBA
06/2013
1MagnesiumIBA
06/2013
1TroponinIBA
06/2013
1tariquidar (XR9576)IBA
02/2011
1Docetaxel (Taxotere)FDA Link
02/2011
1Biological ProductsIBA
12/2010
1AnthracyclinesIBA
12/2010
1Anaplastic Lymphoma KinaseIBA
12/2010
1Azacitidine (5 Azacytidine)FDA Link
06/2009
1PanobinostatIBA
06/2009
1DecitabineFDA Link
06/2009
1ATP-Binding Cassette Transporters (ABC Transporters)IBA
03/2006
1EnzymesIBA
03/2002

Therapy/Procedure

6Therapeutics
10/2021 - 06/2004
3Drug Therapy (Chemotherapy)
01/2018 - 12/2010
2Radiotherapy
10/2018 - 06/2017